Understanding Bone Changes in Human Knee Osteoarthritis
Subchondral Trabecular Plate and Rod Abnormalities in Human Osteoarthritis
This research aims to better understand how bone structure changes in the knee for people with osteoarthritis, especially in its early stages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11101256 on NIH RePORTER |
What this research studies
We want to learn more about why osteoarthritis develops and progresses, as current treatments don't stop the disease. Our team will use advanced imaging techniques, including a special type of CT scan and MRI, to get a detailed look at the bone and cartilage in the knees of people with osteoarthritis. By studying these changes over time, we hope to uncover new insights into how the disease progresses. This could help us identify early signs of osteoarthritis and develop more effective ways to treat it in the future.
Who could benefit from this research
Good fit: Ideal candidates for this type of research would be adults aged 21 and older who have mild, moderate, or no knee osteoarthritis.
Not a fit: Patients with advanced or severe knee osteoarthritis may not directly benefit from this particular early-stage research.
Why it matters
Potential benefit: If successful, this work could provide crucial insights into the early development of knee osteoarthritis, potentially leading to new ways to diagnose and treat the condition before it becomes severe.
How similar studies have performed: Few previous studies have comprehensively quantified subchondral bone microstructure in human knee osteoarthritis, especially in conjunction with cartilage analysis, making this a novel approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Guo, X. Edward — Columbia University Health Sciences
- Study coordinator: Guo, X. Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.