Understanding bone cells in Multiple Myeloma
Contribution of osteocytes to the musculoskeletal effects of Multiple Myeloma
This research explores how certain bone cells called osteocytes influence the growth of Multiple Myeloma and the bone damage it causes, hoping to find new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project ID | NIH-11129822 on NIH RePORTER |
What this research studies
Multiple Myeloma is a cancer that grows in the bone marrow and often leads to severe bone disease, making bones weak and prone to fractures. Even with current treatments, the cancer can return, and the bone damage remains a major challenge. Our team is looking closely at osteocytes, a type of bone cell, because we've found they send signals that help myeloma cells grow and also contribute to bone destruction. We are focusing on a specific signal called FGF23 from these osteocytes, aiming to see if blocking this signal can slow cancer growth, repair bone, and make current treatments work better.
Who could benefit from this research
Good fit: This foundational research is for patients with Multiple Myeloma who are interested in understanding the underlying causes of their disease and potential future treatment options for both the cancer and its associated bone problems.
Not a fit: Patients not diagnosed with Multiple Myeloma or related bone diseases would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that not only fight Multiple Myeloma more effectively but also protect and repair bones, improving patients' quality of life.
How similar studies have performed: Previous work from this team has already shown that targeting interactions between osteocytes and myeloma cells can reduce cancer growth and improve bone health.
Where this research is happening
Little Rock, United States
- Univ of Arkansas for Med Scis — Little Rock, United States (Active)
Researchers
- Principal investigator: Delgado-Calle, Jesus — Univ of Arkansas for Med Scis
- Study coordinator: Delgado-Calle, Jesus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.