Understanding bone and tooth mineralization issues in X-linked hypophosphatemia
Identifying Novel Mechanisms for Dentoalveolar Mineralization Defects in X-linked Hypophosphatemia
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10878803
This study is looking into how a genetic condition called X-linked hypophosphatemia affects bone and tooth health, focusing on how a certain protein might be causing problems, with the goal of finding new treatments to help improve dental and skeletal issues for people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10878803 on ClinicalTrials.gov |
What this research studies
This research investigates the underlying mechanisms that lead to mineralization defects in bones and teeth for individuals with X-linked hypophosphatemia (XLH), a genetic condition caused by mutations in the PHEX gene. The study aims to explore how elevated levels of fibroblast growth factor 23 (FGF23) affect phosphate levels and contribute to these defects. By examining the complex interactions involved in mineralization, the research seeks to identify new treatment strategies that could specifically target dental and skeletal issues associated with XLH. Patients may be involved in trials assessing the effectiveness of novel therapies that could improve their oral health and overall quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with X-linked hypophosphatemia who experience dental and skeletal mineralization defects.
Not a fit: Patients without X-linked hypophosphatemia or those whose mineralization issues are unrelated to this genetic condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for improving dental and skeletal health in patients with X-linked hypophosphatemia.
How similar studies have performed: While there have been studies on FGF23 and its effects, this specific approach to understanding dentoalveolar defects in XLH is novel and has not been extensively tested.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FOSTER, BRIAN LEE — OHIO STATE UNIVERSITY
- Study coordinator: FOSTER, BRIAN LEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.