Understanding Body Clocks and Immune System After Stroke
Circadian Control of Brain-peripheral Immune Response After Stroke
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11131236
This project explores how our body's natural daily rhythms and aging affect the immune system's role in recovery after a stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11131236 on ClinicalTrials.gov |
What this research studies
We know that both our age and our body's internal clock, called the circadian rhythm, strongly influence our immune system. After a stroke, the immune system plays a big part in how the brain heals, but we don't fully understand how aging and daily rhythms work together to affect this process. This project will look closely at how signals travel from the brain to the lymph nodes in the neck, which are important parts of the immune system. By understanding this pathway, we hope to discover new ways that our body clock, age, and immune response are connected in stroke recovery.
Who could benefit from this research
Good fit: This foundational research is relevant to anyone who has experienced a stroke, particularly older individuals, as it seeks to understand the underlying biological processes of recovery.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for timing treatments or developing therapies that work with our body's natural rhythms to improve stroke recovery, especially for older patients.
How similar studies have performed: Previous pilot data and published work from this research group suggest that circadian rhythms significantly influence stroke injury progression and immune responses.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ESPOSITO, ELGA — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: ESPOSITO, ELGA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury