Understanding blood vessel problems in pulmonary arterial hypertension
Official title: Hemodynamic Contributions to Vascular Dysfunction in Pulmonary Arterial Hypertension
Funded at University of Washington · NIH-11051787 · Data updated 2026-11-12
This study is looking at how changes in blood flow and pressure affect the blood vessels in people with pulmonary arterial hypertension (PAH), with the hope of finding new ways to help improve treatment for this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $187,056 |
| NIH project number | 5K08HL166696-03 |
| Project ID | NIH-11051787 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension who are experiencing symptoms related to their condition.
✕Less likely to help
Patients with other forms of pulmonary hypertension or those without a diagnosis of pulmonary arterial hypertension may not benefit from this research.
What this research studies
This research investigates how abnormal blood flow and pressure affect the function of blood vessels in patients with pulmonary arterial hypertension (PAH). By examining the responses of specific cells in the lungs to increased stress, the study aims to uncover the underlying mechanisms that contribute to this serious condition. The research employs advanced bioengineering techniques to analyze how these factors interact and lead to vascular dysfunction. Ultimately, the goal is to identify potential new targets for therapies that could improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or even reverse the effects of pulmonary arterial hypertension.
How similar studies have gone: Previous research has shown promise in understanding vascular dysfunction in similar conditions, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Rayner, Samuel Gibson — University of Washington
- Study coordinator: Rayner, Samuel Gibson
Related research
Other NIH-funded projects on the same topics.
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Understanding how blood flow and pressure affect lungs in PAH
This grant studies how abnormal blood flow and pressure contribute to pulmonary arterial hypertension and how patient factors shape these effects, with the aim of guiding better therapies.
-
Asporin as a double-targeted therapy and biomarker for a serious artery disease
This project tests a protein called asporin as both a treatment and a biomarker for pulmonary arterial hypertension (PAH) to help people with this life-threatening condition.
-
Platelets and fibroblasts linked to energy use in a hard-to-treat blood vessel disease
A research team at the University of Pittsburgh is studying how platelet energy metabolism and fibroblast glutamine use interact in systemic sclerosis-related pulmonary arterial hypertension to improve diagnosis and treatment.
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A biatrial dual‑lumen catheter to help the heart and lungs in pulmonary arterial hypertension
A new double‑lumen catheter is being developed to unload the right side of the heart and protect the lungs for people with pulmonary arterial hypertension.
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Endothelial inflammation and Src kinase in early pulmonary arterial hypertension
Researchers are studying how inflammation in the lining of blood vessels and a protein called Src kinase contribute to early lung artery remodeling in people with mild PAH.
-
Cardiopulmonary chip model to study right heart disease from high blood pressure in the lungs
A tiny heart-lung chip is being developed to understand why the right side of the heart enlarges in people with pulmonary arterial hypertension and to test targeted treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.