Understanding blood vessel problems in pulmonary arterial hypertension
Hemodynamic Contributions to Vascular Dysfunction in Pulmonary Arterial Hypertension
This study is looking at how changes in blood flow and pressure affect the blood vessels in people with pulmonary arterial hypertension (PAH), with the hope of finding new ways to help improve treatment for this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11051787 on NIH RePORTER |
What this research studies
This research investigates how abnormal blood flow and pressure affect the function of blood vessels in patients with pulmonary arterial hypertension (PAH). By examining the responses of specific cells in the lungs to increased stress, the study aims to uncover the underlying mechanisms that contribute to this serious condition. The research employs advanced bioengineering techniques to analyze how these factors interact and lead to vascular dysfunction. Ultimately, the goal is to identify potential new targets for therapies that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension who are experiencing symptoms related to their condition.
Not a fit: Patients with other forms of pulmonary hypertension or those without a diagnosis of pulmonary arterial hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or even reverse the effects of pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promise in understanding vascular dysfunction in similar conditions, indicating that this approach may yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Rayner, Samuel Gibson — University of Washington
- Study coordinator: Rayner, Samuel Gibson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.