Understanding blood vessel problems in diabetes and heart failure
Official title: Mechanisms of VSM dysfunction in diabetes and HFpEF
Funded at University of California at Davis · NIH-10995308 · Data updated 2026-11-12
This study is looking at how diabetes affects blood vessels and aims to understand why some people with diabetes and heart failure have trouble with blood flow and blood pressure, focusing on a specific protein that might play a role in these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $625,989 |
| NIH project number | 5R01HL171014-02 |
| Project ID | NIH-10995308 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes and/or heart failure with preserved ejection fraction (HFpEF).
✕Less likely to help
Patients without diabetes or heart failure may not benefit from this research.
What this research studies
This research investigates how diabetes affects the function of blood vessels, particularly focusing on vascular smooth muscle (VSM) dysfunction. The team aims to uncover the mechanisms behind impaired blood flow and blood pressure regulation in patients with diabetes and heart failure with preserved ejection fraction (HFpEF). By studying a specific protein complex that responds to high glucose levels, the researchers hope to identify how these changes contribute to vascular complications. This work involves advanced biochemical techniques and animal models to explore the role of a protein called pannexin 1 in these processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood vessel function and reduce complications for patients with diabetes and heart failure.
How similar studies have gone: Previous research has shown promising results in understanding vascular dysfunction in diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Navedo, Manuel F — University of California at Davis
- Study coordinator: Navedo, Manuel F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.