Understanding Blood Vessel Leaks in Trauma and Shock
Microvascular Leakage in Hemorrhagic Shock and Trauma
This project aims to understand why small blood vessels leak after severe injury and shock, especially when alcohol is involved, to find new ways to help trauma patients recover better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11123242 on NIH RePORTER |
What this research studies
After a severe injury or shock, tiny blood vessels can leak, which makes recovery harder and can lead to serious complications like organ failure. Our goal is to uncover the exact signals within the body that cause this leakage and how it might be stopped or reversed. We are also looking into how alcohol intoxication, which often occurs with injuries, makes this problem worse. By using advanced techniques to study genes and molecules, we hope to discover new targets for treatments that could save lives and improve recovery for trauma patients.
Who could benefit from this research
Good fit: Patients who experience severe traumatic injuries, especially those with hemorrhagic shock or who have consumed alcohol, are the focus of this research.
Not a fit: Patients with conditions unrelated to traumatic injury, hemorrhagic shock, or microvascular leakage would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent or reduce dangerous blood vessel leakage after severe injuries, improving survival and recovery for trauma patients.
How similar studies have performed: While the general problem of microvascular leakage is known, this research aims to significantly expand current knowledge by using advanced, unbiased molecular approaches to identify novel therapeutic targets.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Breslin, Jerome W — University of South Florida
- Study coordinator: Breslin, Jerome W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.