Understanding blood vessel hardening in kidney disease
The role of MLKL in the regulation of vascular calcification in CKD
This research aims to uncover new ways to prevent blood vessel hardening, a serious problem for people with chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11110327 on NIH RePORTER |
What this research studies
Cardiovascular diseases, like the hardening of blood vessels, are a major cause of death for individuals living with chronic kidney disease, and currently, there are no effective treatments. Our team is exploring how inflammation and cell stress contribute to this hardening. We are specifically looking at a process called regulated cell death to find new targets for medicines. By understanding these underlying mechanisms, we hope to develop new strategies to protect blood vessels.
Who could benefit from this research
Good fit: This foundational research is for patients with chronic kidney disease who are at risk for or experiencing vascular calcification.
Not a fit: Patients without chronic kidney disease or vascular calcification would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new medications that prevent or slow down the hardening of blood vessels in patients with chronic kidney disease.
How similar studies have performed: Previous studies have shown that inflammation and cell stress play a role in vascular calcification, and this work builds on those findings with a novel focus on cell death pathways.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Miyazaki, Makoto — University of Colorado Denver
- Study coordinator: Miyazaki, Makoto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.