Understanding blood vessel development in the brain's choroid plexus
Molecular Genetic Dissection of Fenestrated Vascular Development in the Choroid Plexus
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10869905
This study is looking at how genes help create special blood vessels in the brain using zebrafish, which could help us understand and treat brain blood vessel problems better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10869905 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic mechanisms that control the development of specialized blood vessels in the choroid plexus of the brain. By studying zebrafish, researchers aim to uncover how certain growth factors contribute to the formation of fenestrated blood vessels, which are crucial for brain function. The study employs advanced techniques to analyze vascular development and aims to identify specific genetic pathways involved. This knowledge could lead to better understanding and treatment of cerebrovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to cerebrovascular diseases or those who have experienced acquired brain injuries.
Not a fit: Patients with non-genetic cerebrovascular issues or those without any history of brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for cerebrovascular diseases that significantly improve patient outcomes.
How similar studies have performed: Other research has shown promising results in understanding vascular development in the brain, but this specific focus on fenestrated vessels in the choroid plexus is relatively novel.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATSUOKA, RYOTA — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: MATSUOKA, RYOTA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury