Understanding blood vessel changes and brain degeneration in Alzheimer's disease
Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's Disease
This study is looking at how the health of blood vessels in the brain might affect the progression of Alzheimer's disease, and it aims to find early signs that could help detect the condition sooner, so people with Alzheimer's can participate in tests to help us understand these connections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11013912 on NIH RePORTER |
What this research studies
This research investigates how changes in the blood vessels of the brain relate to the progression of Alzheimer's disease. It focuses on the stiffness and structural breakdown of large cerebral arteries, which may affect brain metabolism and contribute to neurodegeneration. By examining the relationship between cerebrovascular health and the accumulation of harmful substances like Amyloid-β, the study aims to identify potential biomarkers for early detection of Alzheimer's. Patients may be involved in assessments that help clarify these connections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk for developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to detect and treat Alzheimer's disease earlier, potentially improving patient outcomes.
How similar studies have performed: Previous research has indicated that cerebrovascular health is linked to Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston University (Charles River Campus) — Boston, United States (Active)
Researchers
- Principal investigator: Zhang, Yanhang Katherine — Boston University (Charles River Campus)
- Study coordinator: Zhang, Yanhang Katherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.