Understanding Blood Thinners for Older Stroke Patients with Atrial Fibrillation
Balancing Risks and Benefits of Direct Oral Anticoagulants in Older Ischemic Stroke Patients with Atrial Fibrillation
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11132827
This project helps doctors choose the best blood thinner for older patients who have had a stroke and also have an irregular heartbeat called atrial fibrillation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11132827 on ClinicalTrials.gov |
What this research studies
For older patients who have experienced an ischemic stroke and also have atrial fibrillation, choosing the right direct oral anticoagulant (DOAC) can be tricky. While guidelines suggest DOACs over warfarin, the balance of preventing another stroke versus the risk of bleeding is different for these patients. This work uses information from large patient registries and Medicare data to find out how different DOACs compare in terms of how well they work and their safety. The goal is to create better, evidence-based ways to personalize blood thinner treatment for each patient.
Who could benefit from this research
Good fit: This research focuses on older patients who have experienced an ischemic stroke and also have atrial fibrillation.
Not a fit: Patients who have not had an ischemic stroke or do not have atrial fibrillation would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more personalized and safer blood thinner choices, reducing the risk of recurrent strokes and bleeding complications for older patients.
How similar studies have performed: While DOACs are widely used, this research aims to provide new evidence on how their effectiveness and safety compare specifically for older stroke survivors with atrial fibrillation, building upon existing knowledge.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIAN, YING — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: XIAN, YING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.