Understanding blood sugar patterns with continuous glucose monitors to spot future diabetes
Continuous glucose monitoring: determinants and prediction of diabetes mellitus development in the Framingham Heart Study
['FUNDING_R01'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-11323067
We use wearable continuous glucose monitors on adults to find blood sugar patterns that may signal future development of type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11323067 on ClinicalTrials.gov |
What this research studies
If you join, you'll wear a small continuous glucose sensor that records your blood sugar throughout the day and night. The study will include about 2,700 adults from the Framingham Heart Study and a multi-ethnic cohort, and researchers will link the sensor data to blood tests, gut microbiome samples, diet and activity records, family history, and genetic risk scores. They'll measure things like time spent in healthy blood sugar ranges, spikes or dips, average glucose, and variability. The team will use these patterns and personal factors to see which people are more likely to develop type 2 diabetes over time.
Who could benefit from this research
Good fit: Ideal candidates are adults (21+) without diagnosed diabetes or with prediabetes who can wear a glucose sensor and provide blood and other health samples and information, especially those enrolled in the Framingham/Omni cohorts.
Not a fit: People with established insulin-treated diabetes, those unable or unwilling to wear a sensor, or those not part of the Framingham/Omni cohorts are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this could help identify people at higher risk earlier and allow targeted prevention to stop or delay type 2 diabetes.
How similar studies have performed: Other studies show continuous glucose monitoring reveals hidden glucose spikes and helps diabetes care, but using CGM in large community cohorts to predict future diabetes is a relatively new approach.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPARTANO, NICOLE L — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: SPARTANO, NICOLE L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus