Understanding blood stem cell problems in sickle cell disease
Investigating hematopoietic stem cell dysfunction during sickle cell disease
['FUNDING_R01'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-11059857
This study is looking at how long-term inflammation and stress impact the blood-making stem cells in people with sickle cell disease, with the goal of finding better treatments for those who may not be getting the help they need from current options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11059857 on ClinicalTrials.gov |
What this research studies
This research investigates how chronic inflammation and stress affect blood-sustaining stem cells in patients with sickle cell disease (SCD). By examining the health and function of these stem cells, the study aims to uncover the mechanisms behind their dysfunction and the potential for developing better treatments. The researchers will analyze blood samples and use advanced techniques like RNA sequencing to identify changes in stem cell behavior and characteristics. This work is crucial for improving therapies for SCD, especially for patients who may not respond well to current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with sickle cell disease, particularly those experiencing complications related to blood stem cell function.
Not a fit: Patients without sickle cell disease or those with other unrelated blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies and better management of sickle cell disease, enhancing patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding blood stem cell dysfunction in related conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCKINNEY-FREEMAN, SHANNON L — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: MCKINNEY-FREEMAN, SHANNON L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.