Understanding blood flow regulation after traumatic brain injury
Official title: Sympathetic Activation and Cerebrovascular Pressure Reactivity after Traumatic Brain Injury (TBI)
Funded at Ut Southwestern Medical Center · NIH-11092791 · Data updated 2026-11-12
This study is looking at how a traumatic brain injury affects blood flow in the brain and how this might impact recovery for people with moderate to severe injuries, using safe and simple methods to measure changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $457,448 |
| NIH project number | 5R01NS133245-03 |
| Project ID | NIH-11092791 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have experienced moderate to severe traumatic brain injury.
✕Less likely to help
Patients with mild traumatic brain injury or those who are not within the age range of 21 and older may not benefit from this research.
What this research studies
This research investigates how traumatic brain injury (TBI) affects the regulation of blood flow in the brain, particularly focusing on cerebrovascular pressure reactivity (CVPR). It aims to explore the long-term effects of impaired CVPR on recovery and functional outcomes in individuals who have experienced moderate to severe TBI. By using non-invasive techniques like transcranial Doppler ultrasound, the study seeks to measure changes in blood flow regulation without the need for invasive monitoring. The ultimate goal is to improve prognostication and treatment strategies for TBI patients.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of recovery processes in TBI patients, potentially improving their long-term outcomes.
How similar studies have gone: Previous research has shown promise in using non-invasive methods to assess cerebrovascular function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Pinto, Shanti Marie — Ut Southwestern Medical Center
- Study coordinator: Pinto, Shanti Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.