Understanding blood flow issues in small coronary blood vessels
Vascular dysfunction in coronary microcirculation
This study looks at how problems with tiny blood vessels in the heart can affect heart health, especially after a heart attack, and it aims to find ways to improve blood flow by understanding how a key molecule called nitric oxide is impacted during heart injury, which could help patients manage or prevent issues related to coronary heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-10978214 on NIH RePORTER |
What this research studies
This research investigates how vascular dysfunction in the coronary microcirculation contributes to heart conditions, particularly after events like heart attacks. The study focuses on the role of nitric oxide, an important molecule for blood vessel relaxation, and how its production is affected during injury to the heart. By examining the mechanisms that lead to the loss of nitric oxide production, the research aims to identify potential interventions that could improve blood flow and heart health. Patients may benefit from insights gained about how to better manage or prevent complications related to coronary heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from coronary heart disease or those who have experienced a myocardial infarction.
Not a fit: Patients with non-cardiovascular related conditions or those without any history of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and reduce heart damage in patients with coronary heart disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of nitric oxide in cardiovascular health, indicating that this approach has potential for success.
Where this research is happening
Lubbock, United States
- Texas Tech University Health Scis Center — Lubbock, United States (Active)
Researchers
- Principal investigator: Das, Kumuda C — Texas Tech University Health Scis Center
- Study coordinator: Das, Kumuda C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.