Understanding blood flow changes in diabetic retinopathy
Official title: Development and application of a high-fidelity computational model of diabetic retinopathy hemodynamics: Coupling single-cell biophysics with retinal vascular network topology and complexity
Funded at Rutgers, the State Univ of N.j. · NIH-10887584 · Data updated 2026-11-12
This study looks at how diabetes impacts blood flow and the tiny blood vessels in the eye, which can cause vision issues, and aims to create a model that helps us understand these changes better, ultimately hoping to improve how we diagnose and treat diabetic eye problems for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | September 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $337,450 |
| NIH project number | 5R01EY033003-04 |
| Project ID | NIH-10887584 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are at risk of developing diabetic retinopathy.
✕Less likely to help
Patients without diabetes or those who do not have any retinal vascular abnormalities may not benefit from this research.
What this research studies
This research investigates how diabetes affects blood flow and the structure of blood vessels in the retina, which can lead to vision problems. By developing a detailed computational model, the study aims to link the physical properties of blood cells with the complex network of retinal blood vessels. This approach will help identify how changes in blood flow and vessel structure contribute to the progression of diabetic retinopathy. Patients may benefit from insights gained through this research, which could lead to improved diagnostic and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of diabetic retinopathy, potentially preserving vision for patients.
How similar studies have gone: While there have been studies on diabetic retinopathy, this specific approach using high-fidelity computational modeling is relatively novel and untested.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Bagchi, Prosenjit — Rutgers, the State Univ of N.j.
- Study coordinator: Bagchi, Prosenjit
Related research
Other NIH-funded projects on the same topics.
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Creating a computer model to understand blood flow changes in diabetic retinopathy
This study is creating a computer model to better understand how diabetes affects blood flow in the eyes of people with diabetic retinopathy, helping to reveal how these changes can lead to eye problems that current tests might miss.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.