Understanding Blood Flow and Muscle Fatigue After Stroke
Blood Flow Regulation and Neuromuscular Function Post-Stroke
This research explores why people feel extra tired in their muscles after a stroke, focusing on how blood flow might play a role.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11132884 on NIH RePORTER |
What this research studies
Many stroke survivors experience increased muscle fatigue, which can make everyday tasks like walking much harder. This project suggests that a key reason for this fatigue might be that muscles don't get enough blood flow during exercise. Researchers believe that a natural process called functional sympatholysis, which helps active muscles receive sufficient blood, may not work correctly after a stroke. This work aims to understand if this problem with blood flow regulation makes muscle fatigue worse and limits a person's ability to move and function.
Who could benefit from this research
Good fit: Patients who have experienced a stroke and struggle with muscle fatigue during daily activities or exercise might be ideal candidates for future related studies.
Not a fit: Patients whose fatigue is not related to blood flow regulation or neuromuscular function may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies to reduce muscle fatigue and improve physical abilities for stroke survivors.
How similar studies have performed: While the specific mechanisms of blood flow dysregulation and fatigue post-stroke are understudied, recent data indicate a connection, making this a novel exploration building on emerging insights.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Durand, Matthew J — Medical College of Wisconsin
- Study coordinator: Durand, Matthew J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.