Understanding blood flow and metabolism issues in children with cerebral malaria
Official title: Determining Mechanisms of Cerebral Blood Flow and Metabolism Derangements in Pediatric Cerebral Malaria (FLOW)
Funded at Research Inst Nationwide Children's Hosp · NIH-11045098 · Data updated 2026-11-12
This study is looking at how cerebral malaria impacts blood flow and energy use in children's brains, with the goal of finding better ways to help them recover.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | May 15, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $490,977 |
| NIH project number | 1R56NS132781-01A1 |
| Project ID | NIH-11045098 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are diagnosed with cerebral malaria.
✕Less likely to help
Patients who are not diagnosed with cerebral malaria or are older than 11 years may not benefit from this research.
What this research studies
This research investigates how cerebral malaria affects blood flow and metabolism in children, aiming to uncover the mechanisms behind these changes. By using advanced imaging techniques like Transcranial Doppler Ultrasound, the study will analyze different patterns of blood flow and their relationship to neurological outcomes. The research will focus on identifying how various factors influence blood vessel function and metabolism in the brain, which could lead to better treatment strategies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that reduce mortality and long-term neurological damage in children suffering from cerebral malaria.
How similar studies have gone: Previous research has shown promising results in understanding cerebral blood flow dynamics in similar conditions, indicating that this approach may yield valuable insights.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Obrien, Nicole — Research Inst Nationwide Children's Hosp
- Study coordinator: Obrien, Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.