NIH-funded research Career grant

Understanding blood flow and brain health related to dementia

Official title: Vascular hemodynamics and markers of preclinical and subclinical vascular brain injury and dementia

Funded at Vassar College · NIH-11003670 · Data updated 2026-11-12

This study is looking at how blood flow in the brain might be connected to early signs of dementia and other brain issues, using special scans to help us understand how brain health and blood vessel health are linked, especially for people who might be at higher risk.

More Dementia research and trials

Quick facts

Grant typeCareer grant
Study typeNIH-funded research
Funding institutionVassar College
NIH-funded
Lab location1 site (Poughkeepsie, United States)
Project startJanuary 1, 2022
Project endDecember 31, 2026
Funding year2025
Award (this year)$146,459
NIH project number5K01HL161494-04
Project IDNIH-11003670 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include individuals at risk for dementia, particularly those with cardiovascular issues or a family history of Alzheimer's disease.

Less likely to help

Patients who are already diagnosed with advanced dementia or those without any vascular risk factors may not benefit from this research.

What this research studies

This research investigates how blood flow dynamics in the brain may relate to early signs of dementia and vascular brain injury. It involves advanced imaging techniques like MRI and PET scans to assess brain health and vascular conditions. The project aims to enhance understanding of the relationship between vascular health and cognitive decline, particularly in populations at risk. The research will also provide training for the investigator to become an independent researcher in this critical area.

Why it matters

Potential benefit: If successful, this research could lead to improved early detection and prevention strategies for dementia and related vascular conditions.

How similar studies have gone: Previous research has shown promising results in understanding the link between vascular health and cognitive decline, indicating that this approach is grounded in established findings.

Where this research is happening

  • Vassar College
    Poughkeepsie, United States
    Active

Researchers

  • Principal investigator: Cooper, Leroy Leon — Vassar College
  • Study coordinator: Cooper, Leroy Leon

Related research

Other NIH-funded projects on the same topics.

  • Traumatic Brain Injury Across Life: How TBI Relates to Later Dementia Risk

    This study looks at how head injuries over a person’s life affect their chances of developing Alzheimer's disease or related dementias later on.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11449670

  • Cis-proline tau toxicity in brain injury and dementia

    Aims to understand how a specific toxic form of tau protein appears after brain injury and contributes to Alzheimer’s-related dementia, and how early intervention might protect neurons.

    NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11386513

  • Harmful tau protein changes after brain injury and vascular dementia

    This project will try blocking a harmful form of tau protein and boosting a protective neuron response to help people with traumatic brain injury or vascular-related dementia.

    NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11173784

  • Investigating how a specific protein contributes to brain damage in Alzheimer's and related conditions

    This study is looking at how a specific form of a protein called cis P-tau might contribute to Alzheimer's disease and other brain issues, especially after injuries or reduced blood flow, to find new ways to protect brain cells and improve treatments for people affected by these conditions.

    NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11142679

  • Investigating how certain enzymes affect recovery from brain injuries and dementia.

    This study is looking at how certain enzymes might help the brain heal after a traumatic brain injury and how they could be connected to dementia, with the hope that what we learn could lead to better treatments for both conditions.

    NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-11088216

  • Investigating how traumatic brain injury may lead to dementia.

    This study is looking at how a traumatic brain injury (TBI) might increase the chances of developing dementia, and it’s for anyone who has had a TBI and wants to help us understand how it affects brain health over time.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11082476

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.