Understanding blood clotting issues related to cancer immunotherapy
Official title: Mechanisms of cancer immunotherapy-associated thrombosis
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11076344 · Data updated 2026-11-12
This study is looking into why some cancer patients who receive immunotherapy might have issues with blood clotting, aiming to understand how the treatment can sometimes lead to this problem, so we can make it safer and more effective for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $648,664 |
| NIH project number | 5R01HL164516-03 |
| Project ID | NIH-11076344 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who are receiving immune checkpoint inhibitors and may be at risk for thrombosis.
✕Less likely to help
Patients who are not undergoing cancer treatment or those who are not receiving immune checkpoint inhibitors may not benefit from this research.
What this research studies
This research investigates the mechanisms behind blood clotting problems that can occur in patients receiving cancer immunotherapy, specifically those treated with immune checkpoint inhibitors. The study aims to understand how these therapies, which enhance the immune response against tumors, may inadvertently lead to increased clotting risks. By using animal models, researchers will explore the relationship between tumor inflammation and the activation of clotting factors, providing insights into this serious side effect. The goal is to identify the underlying causes of these complications to improve patient safety and treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for patients undergoing cancer immunotherapy, reducing the risk of thrombosis and improving overall treatment safety.
How similar studies have gone: While there is limited information on the specific mechanisms of thrombosis related to immunotherapy, the study addresses a significant gap in understanding this emerging clinical issue, making it a novel investigation.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Mccrae, Keith R. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Mccrae, Keith R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.