Understanding blood clotting issues in COVID-19 patients
Official title: Mechanisms of Thrombosis in SARS CoV-2 Infection
Funded at University of Kentucky · NIH-11050014 · Data updated 2026-11-12
This study is looking at how COVID-19 can cause tiny blood clots that might harm your body, and it's for people who have had COVID-19 to help find ways to prevent these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $503,637 |
| NIH project number | 1R01HL172844-01A1 |
| Project ID | NIH-11050014 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have had COVID-19 and are experiencing symptoms related to blood clotting or microclots.
✕Less likely to help
Patients who have not had COVID-19 or those without any symptoms related to blood clotting may not benefit from this research.
What this research studies
This research investigates how COVID-19 can lead to dangerous blood clotting problems, particularly focusing on small clots known as microclots that can cause tissue damage. The study aims to understand the mechanisms behind these clots, including how certain proteins in the blood are affected during the acute phase of the infection. By examining the interactions between various blood components, the researchers hope to identify potential treatments to prevent these complications. Patients who have experienced COVID-19 may provide valuable insights into these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for preventing blood clot-related complications in COVID-19 patients.
How similar studies have gone: Other research has indicated that understanding blood clotting mechanisms in viral infections can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Wood, Jeremy P — University of Kentucky
- Study coordinator: Wood, Jeremy P
Related research
Other NIH-funded projects on the same topics.
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How COVID-19 causes blood clots and tiny microclots
This work looks at why people with COVID-19 develop blood clots and tiny microclots that may lead to lasting tissue damage.
-
How COVID-19 infection and genes may influence memory and dementia risk
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Alzheimer’s-related dementia after COVID-19: how SARS-CoV-2 affects the brain and potential drug repurposing
This research looks at how COVID-19 may contribute to dementia by studying brain inflammation, blood vessel injury, and virus-host interactions, with the goal of finding existing drugs that could help.
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A short study to understand how the cytokine IL-22 might help protect tissues during and after COVID-19 infection, especially in people with complications related to acute graft-versus-host disease.
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Maternal SARS-CoV-2 infection and its effects on placenta and child development
This grant studies how COVID-19 infection during pregnancy might change the placenta and influence a child’s brain development, especially in kids who may be at higher genetic risk for ADHD/ASD.
-
How COVID-19 and genetics influence memory and dementia risk in older adults
This project studies how getting COVID-19 interacts with people’s genetic makeup to affect the likelihood of cognitive decline and Alzheimer’s disease in older adults from diverse backgrounds.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.