Understanding blood clotting in heart valves after replacement surgery
Computational and Experimental Modeling of Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves
This study is looking at how blood clots form on heart valves used in surgeries, so doctors can better understand the risks and choose the best options for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11001997 on NIH RePORTER |
What this research studies
This research focuses on creating advanced computer models to understand how blood clots form on bioprosthetic heart valves after surgeries like transcatheter or surgical aortic valve replacement. By studying these mechanisms, the research aims to improve how doctors assess risks and choose the best devices for patients. The project involves both experimental and clinical validation to ensure the models accurately reflect real-world scenarios. This could lead to better management of patients who undergo these procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing transcatheter or surgical aortic valve replacement, particularly those at risk for subclinical leaflet thrombosis.
Not a fit: Patients who have not undergone aortic valve replacement or those with other unrelated heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved patient outcomes by reducing the risk of blood clots and associated complications after heart valve replacement.
How similar studies have performed: Previous research has indicated that understanding the mechanisms of thrombosis in heart valves can lead to significant advancements in patient care, suggesting that this approach has potential for success.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Griffith, Boyce Eugene — Univ of North Carolina Chapel Hill
- Study coordinator: Griffith, Boyce Eugene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.