Understanding blood clotting and its regulation
Hemostasis and Thrombosis: Chemistry, Biology and Physiology
['FUNDING_P01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10768826
This study is looking at how certain proteins work together to help your blood clot properly, which could lead to better treatments for people with blood clotting disorders.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10768826 on ClinicalTrials.gov |
What this research studies
This research investigates the complex processes involved in blood coagulation, focusing on how specific proteins interact to regulate clot formation. By examining the roles of various enzymes and cofactors, the research aims to uncover the molecular mechanisms that govern these critical reactions. Patients may benefit from insights gained into blood coagulation disorders, which could lead to improved treatments and therapies. The approach includes advanced techniques such as atomic force microscopy and the use of RNA aptamers to develop targeted inhibitors.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known blood coagulation disorders or those at risk for conditions such as stroke or cardiac infarction.
Not a fit: Patients with unrelated health conditions or those not experiencing blood coagulation issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for patients with blood coagulation disorders, reducing the risk of bleeding or clotting complications.
How similar studies have performed: Previous research has shown promising results in understanding blood coagulation mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRISHNASWAMY, SRIRAM — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: KRISHNASWAMY, SRIRAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.