Understanding blood clotting and inflammation during life support
The role of contact pathway factors in mechanical circulation
This research aims to better understand why patients on heart-lung machines experience dangerous blood clots and inflammation, hoping to find safer ways to prevent these problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11142402 on NIH RePORTER |
What this research studies
When patients need machines like ECMO or cardiopulmonary bypass to support their heart and lungs, they often face serious issues with blood clots and inflammation. Current medications to prevent clots can cause severe bleeding, yet still don't fully stop dangerous clotting. This project explores how a specific protein, Factor XII, contributes to both clotting and inflammation during mechanical life support. By understanding these mechanisms, we hope to develop new, safer treatments that can protect patients from these life-threatening complications.
Who could benefit from this research
Good fit: This research is relevant for patients who require or may require mechanical circulatory support, such as ECMO or cardiopulmonary bypass, and are at risk for blood clots and inflammation.
Not a fit: Patients not undergoing mechanical circulatory support or those without issues related to blood clotting and inflammation during such procedures may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new, more effective, and safer ways to prevent blood clots and inflammation in patients undergoing mechanical circulatory support.
How similar studies have performed: While the specific mechanisms linking Factor XII to mechanical circulation-associated thromboinflammation are under-studied, there is existing interest in Factor XII as a target for anticoagulation.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Palumbo, Joseph S. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Palumbo, Joseph S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.