Understanding blood clots caused by COVID-19 and exploring new treatments
Official title: Determinants of COVID19-induced venous thrombosis and targeted therapy assessed with bioengineered vein-chip
Funded at Boston University Medical Campus · NIH-10857160 · Data updated 2026-11-12
This study is looking at how COVID-19 might cause blood clots in veins, which can lead to serious problems like strokes, and it's for anyone interested in understanding how the virus affects blood flow and what new treatments might help prevent these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $705,488 |
| NIH project number | 5R01HL157790-04 |
| Project ID | NIH-10857160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with COVID-19 who are at risk of developing venous thrombosis.
✕Less likely to help
Patients who have not contracted COVID-19 or those without risk factors for venous thrombosis may not benefit from this research.
What this research studies
This research investigates how COVID-19 can lead to the formation of blood clots in veins, which can result in serious complications like strokes. Using a bioengineered vein-chip model, the study aims to analyze the interactions between the virus, blood components, and the cells lining the blood vessels. By examining these factors, researchers hope to identify the underlying mechanisms of venous thrombosis in COVID-19 patients and develop targeted therapies to prevent these dangerous outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of blood clots in COVID-19 patients, improving their overall health outcomes.
How similar studies have gone: Other research has shown promising results in understanding thromboinflammation in COVID-19, making this approach both relevant and potentially impactful.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Connor, John H — Boston University Medical Campus
- Study coordinator: Connor, John H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.