Understanding blood clots and testing new treatments using advanced 3D models
Official title: High-throughput Imaging-integrated Vascular Model for Understanding Thromboembolism and Therapeutics Screening
Funded at Brigham and Women's Hospital · NIH-11232762 · Data updated 2026-11-12
This study is looking at how blood clots form and how we can treat them better, especially for people with conditions like deep vein thrombosis and pulmonary embolism, using special 3D models that act like human cells to test new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $79,469 |
| NIH project number | 3R01HL166522-03S1 |
| Project ID | NIH-11232762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for venous thromboembolism, such as those with a history of deep vein thrombosis or pulmonary embolism.
✕Less likely to help
Patients who do not have any history of blood clotting disorders or related conditions may not benefit from this research.
What this research studies
This research investigates how blood clots form and how they can be treated, focusing on a condition known as venous thromboembolism (VTE). By using advanced three-dimensional (3D) human cell-based models, the study aims to better mimic human physiology and improve the testing of potential therapies. Patients may benefit from the development of more effective treatments for conditions related to blood clots, such as deep vein thrombosis and pulmonary embolism. The research will also involve real-time monitoring of how these models respond to infections and drug treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for blood clot-related conditions, potentially reducing mortality and improving patient outcomes.
How similar studies have gone: Previous research using 3D human cell models has shown promise in improving drug testing and understanding disease mechanisms, indicating a potential for success in this novel approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Zhang, Y. Shrike — Brigham and Women's Hospital
- Study coordinator: Zhang, Y. Shrike
Related research
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.