Understanding blood cell production in heart disease
Hematopoiesis in Cardiovascular Disease
['FUNDING_P01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11012925
This study is looking at how your body makes blood cells, especially the ones that help fight inflammation, and how these cells can affect heart health, with the goal of finding new ways to help people with heart disease, especially those dealing with a lot of inflammation.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11012925 on ClinicalTrials.gov |
What this research studies
This research investigates how blood cells, particularly leukocytes, are produced in the bone marrow and their role in cardiovascular disease. It focuses on the relationship between inflammation and heart conditions, especially how immune cells can both protect and harm cardiovascular tissues. By exploring the mechanisms of hematopoiesis, or blood cell formation, the research aims to identify new therapeutic targets for treating heart disease, particularly in patients with high inflammation levels. The approach includes studying how cardiovascular risk factors influence blood cell production and the subsequent impact on heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular disease who exhibit high levels of inflammation or related risk factors.
Not a fit: Patients without cardiovascular disease or those who do not exhibit significant inflammatory responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target inflammation in heart disease, potentially reducing the risk of heart attacks and improving patient outcomes.
How similar studies have performed: Previous research has shown promise in targeting inflammation for treating autoimmune and oncological diseases, suggesting potential for success in cardiovascular applications as well.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAHRENDORF, MATTHIAS — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: NAHRENDORF, MATTHIAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.