Understanding blood cell production and disorders like anemia
Official title: Cellular and Molecular Control of Normal and Disordered Erythropoiesis
Funded at Feinstein Institute for Medical Research · NIH-11030218 · Data updated 2026-11-12
This study is looking at how blood cell production can go wrong in conditions like Diamond Blackfan anemia and sickle cell disease, and it aims to find out how certain drugs might help improve this process, especially by understanding the role of bone marrow structures in both babies and adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2031 |
| Funding year | 2025 |
| Award (this year) | $853,132 |
| NIH project number | 5R35HL171168-02 |
| Project ID | NIH-11030218 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Diamond Blackfan anemia, sickle cell disease, or other related blood disorders.
✕Less likely to help
Patients with blood disorders not related to erythropoiesis or those without a diagnosis of anemia may not benefit from this research.
What this research studies
This research investigates how blood cell production, known as erythropoiesis, can become disrupted in conditions such as Diamond Blackfan anemia and sickle cell disease. By examining the differences in blood cell production between newborns and adults, the researchers aim to uncover the mechanisms behind these disorders and explore how certain drugs can enhance blood cell production. The study will also focus on the role of specialized structures in the bone marrow that support blood cell development, particularly under inflammatory conditions. Patients may benefit from new insights into potential treatments and targets for these blood disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from various blood disorders, improving their quality of life.
How similar studies have gone: Previous research has shown promise in understanding blood disorders and developing treatments, indicating that this approach could yield significant advancements.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Blanc, Lionel — Feinstein Institute for Medical Research
- Study coordinator: Blanc, Lionel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.