Understanding blood cell issues in infants born to mothers treated for HIV
Official title: Deciphering hematopoietic stem cell defects in HIV exposed, uninfected infants born to ART-treated mothers
Funded at University of Maryland Baltimore · NIH-11086165 · Data updated 2026-11-12
This study looks at how being exposed to HIV while in the womb affects the blood cell development of babies who aren't infected, especially those born to moms on HIV treatment, to help understand why these babies might get sick more often.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 8, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $681,699 |
| NIH project number | 5R01AI183982-02 |
| Project ID | NIH-11086165 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants aged 0-4 weeks who were born to mothers treated for HIV.
✕Less likely to help
Patients who are older than 11 years or those who are HIV-infected themselves may not benefit from this research.
What this research studies
This research investigates how exposure to HIV in the womb affects the blood cell development of infants who are not infected with the virus. It focuses on understanding the specific defects in hematopoietic stem cells of these infants, particularly those born to mothers receiving antiretroviral therapy. By examining the physiological impacts of maternal HIV exposure, the study aims to uncover the reasons behind the increased risk of infections and health complications in these children. The research employs advanced cellular and molecular techniques to explore these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes and targeted interventions for infants exposed to HIV in utero.
How similar studies have gone: While there has been significant research on HIV's effects on infected individuals, this specific investigation into HIV-exposed uninfected infants is relatively novel and untested.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Rathinam, Chozha Vendan — University of Maryland Baltimore
- Study coordinator: Rathinam, Chozha Vendan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.