Understanding blood cell issues in autoimmune diseases
Official title: The Mechanism of Hematological Abnormalities in Systemic Autoimmunity
Funded at New York University School of Medicine · NIH-11112957 · Data updated 2026-11-12
This study is looking at how autoimmune diseases like lupus can affect the way your body makes blood cells, which might cause issues like anemia and low platelet counts, and it aims to find out if the stem cells that produce blood are not working properly in people with lupus, using mice to help understand this better and hopefully improve treatments for those affected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $216,113 |
| NIH project number | 1R21AR085741-01 |
| Project ID | NIH-11112957 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus or other systemic autoimmune diseases experiencing blood cell abnormalities.
✕Less likely to help
Patients without autoimmune diseases or those not experiencing hematological complications may not benefit from this research.
What this research studies
This research investigates how systemic autoimmune diseases, like systemic lupus erythematosus (SLE), affect blood cell production and lead to complications such as anemia and low platelet counts. The study aims to explore the role of hematopoietic stem cells in these conditions, hypothesizing that these stem cells may be impaired in patients with SLE. By using mouse models, researchers will analyze the function and health of these stem cells to better understand the underlying mechanisms of hematological abnormalities. The findings could lead to improved treatment strategies for patients suffering from these debilitating symptoms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood cell production and reduce complications for patients with autoimmune diseases.
How similar studies have gone: Previous research has shown promising results in understanding blood cell formation in autoimmune conditions, but this specific approach focusing on hematopoietic stem cells in SLE is relatively novel.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Reizis, Boris — New York University School of Medicine
- Study coordinator: Reizis, Boris
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.