Understanding blood cell development in myeloid disorders
Defining malignant hematopoiesis via single-cell multi-omics
This study is looking at how changes in your genes can impact the way your blood cells develop if you have a myeloid disorder, and it's using advanced technology to help find new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10912515 on NIH RePORTER |
What this research studies
This research investigates how genetic mutations affect the development of blood cells in patients with myeloid disorders. Using a cutting-edge technique called single-cell multi-omics, the researchers analyze individual blood cells to differentiate between normal and mutated cells. This approach allows for a detailed understanding of how these mutations disrupt normal blood cell formation and function. By identifying specific pathways that are altered in mutated cells, the research aims to uncover potential new treatment targets for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with myeloid disorders, particularly those with calreticulin mutations.
Not a fit: Patients without myeloid disorders or those who do not have the specific genetic mutations being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with myeloid disorders by identifying specific pathways to target.
How similar studies have performed: Other research has shown promise in using single-cell multi-omics to study blood disorders, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Nam, Seung Ha — Weill Medical Coll of Cornell Univ
- Study coordinator: Nam, Seung Ha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.