Understanding blood cell changes related to knee osteoarthritis
Peripheral blood mononuclear cell epigenetic associations in and biomarkers for knee osteoarthritis development and progression
This study is looking at how changes in your blood cells' DNA might help us understand and predict how quickly knee osteoarthritis gets worse, so we can find a simple and affordable way to spot it early.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10843112 on NIH RePORTER |
What this research studies
This research investigates how changes in the DNA of peripheral blood cells are linked to the development and progression of knee osteoarthritis (OA). By analyzing blood samples from patients, the study aims to identify specific epigenetic patterns that could predict rapid progression of OA over a two-year period. Advanced machine learning techniques will be used to develop algorithms that can distinguish between patients who will experience significant OA progression and those who will not. The findings may lead to the creation of a more accessible and cost-effective testing method for early detection of OA.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of developing knee osteoarthritis or those already experiencing early symptoms.
Not a fit: Patients with advanced knee osteoarthritis or those who do not have knee-related symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new way to predict and potentially prevent the progression of knee osteoarthritis in patients.
How similar studies have performed: Previous research has shown promise in using epigenetic markers for predicting disease progression, suggesting that this approach may yield valuable insights.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Jeffries, Matlock — Oklahoma Medical Research Foundation
- Study coordinator: Jeffries, Matlock
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.