Understanding blood cell changes related to aging and health risks in diverse populations
Clonal Hematopoiesis in a Biracial Population
This study is looking at how certain factors like race, income, and lifestyle might affect a condition called clonal hematopoiesis of indeterminate potential (CHIP), which can raise the risk of cancer and heart disease, and it's for adults aged 45 and older who want to help us learn more about who might be at higher risk for this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11081667 on NIH RePORTER |
What this research studies
This research investigates clonal hematopoiesis of indeterminate potential (CHIP), a condition where blood cells expand due to mutations in stem cells, which can increase the risk of cancers and cardiovascular diseases. The study will analyze various factors such as race, socioeconomic status, and health behaviors that may influence the development and progression of CHIP. By examining a large group of adults aged 45 and older, the research aims to identify individuals at higher risk for CHIP using advanced genetic sequencing techniques. Participants will contribute to a better understanding of how these factors interact and affect health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 45 and older, particularly those from diverse racial backgrounds and varying socioeconomic statuses.
Not a fit: Patients under the age of 45 or those without any risk factors for CHIP may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for individuals at risk of hematologic cancers and cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding CHIP, but this study aims to explore new factors and utilize advanced sequencing techniques, making it a novel approach.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Gangaraju, Radhika — University of Alabama at Birmingham
- Study coordinator: Gangaraju, Radhika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.