Understanding bladder pain and function related to stress and injury
PACAP/PAC1 receptor signaling in micturition neurocircuits: effects of stress and injury/inflammation
This research explores how stress and injury affect bladder control and pain in conditions like Bladder Pain Syndrome/Interstitial Cystitis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11163409 on NIH RePORTER |
What this research studies
Many people experience chronic pelvic pain and urinary symptoms, especially when stressed, but we don't fully understand why. This project looks at how stress and injury change the signals in the brain and nerves that control bladder function and pain. We want to learn how these changes lead to increased urinary frequency and pelvic pain, focusing on specific signaling pathways. By understanding these mechanisms, we hope to find new ways to help manage these challenging symptoms.
Who could benefit from this research
Good fit: Patients experiencing chronic pelvic pain, bladder dysfunction, or symptoms of Bladder Pain Syndrome/Interstitial Cystitis may find this research relevant to their condition.
Not a fit: Patients without bladder pain, urinary symptoms, or related chronic pelvic conditions may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or better ways to manage symptoms for individuals with Bladder Pain Syndrome/Interstitial Cystitis.
How similar studies have performed: This project builds upon previous collaborative work, integrating diverse scientific disciplines to explore novel aspects of bladder pain and stress responses.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Vizzard, Margaret Ann — University of Vermont & St Agric College
- Study coordinator: Vizzard, Margaret Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.