Understanding bladder function changes in older adults
Bladder Mucosal Dysfunction During Aging
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10371207
This study is looking at how getting older affects bladder health and causes issues like leaking urine, especially in older adults, by exploring changes in bladder cells and how they might be influenced by stress on the body.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10371207 on ClinicalTrials.gov |
What this research studies
This research investigates how aging affects the bladder's normal functioning, particularly focusing on lower urinary tract symptoms like urinary incontinence in elderly individuals. The study aims to explore the role of the urothelium, a layer of cells in the bladder, and how its changes due to aging contribute to bladder dysfunction. By using an aging rat model, researchers will examine the impact of oxidative stress on bladder cell signaling and overall bladder health. The findings could lead to better understanding and treatment options for urinary issues in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing lower urinary tract symptoms, particularly urinary incontinence.
Not a fit: Patients who are younger or do not have urinary tract symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for urinary incontinence and other bladder-related issues in the elderly.
How similar studies have performed: Previous research has shown promising results in understanding bladder function changes with aging, but this specific focus on urothelial signaling is relatively novel.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BIRDER, LORI A — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: BIRDER, LORI A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.