Understanding bladder dysfunction and pain caused by cystitis
Cystitis-induced bladder dysfunction and pain
This study looks at how cystitis, which causes bladder pain and urinary issues, can get worse with stress, and it aims to understand the biological reasons behind this to find new ways to help people who suffer from these symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10763353 on NIH RePORTER |
What this research studies
This research investigates how cystitis, a condition causing bladder inflammation, leads to chronic pelvic pain and urinary symptoms. It explores the relationship between stress and the worsening of these symptoms, aiming to uncover the underlying biological mechanisms. The study employs innovative animal models to simulate the condition and assess how stress impacts bladder function and pain perception. By examining specific signaling pathways and their effects on bladder sensitivity, the research seeks to identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with bladder pain syndrome or interstitial cystitis who experience chronic pelvic pain and urinary symptoms.
Not a fit: Patients without a diagnosis of bladder pain syndrome or interstitial cystitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from bladder pain syndrome and interstitial cystitis.
How similar studies have performed: Previous research has shown promise in understanding bladder pain mechanisms, but this approach is innovative and aims to fill critical gaps in knowledge.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Vizzard, Margaret Ann — University of Vermont & St Agric College
- Study coordinator: Vizzard, Margaret Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.