Understanding biomarkers in pancreatic neuroendocrine tumors
The Prognostic Significance and Mechanistic Determination of Chromatin Remodeling Biomarkers in Non-Functional Pancreatic Neuroendocrine Tumor
This study is looking at certain genetic markers in non-functional pancreatic neuroendocrine tumors to see if they can help doctors understand how these tumors might behave and spread, which could lead to better treatment options for patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10906820 on NIH RePORTER |
What this research studies
This research investigates the role of specific biomarkers related to chromatin remodeling in non-functional pancreatic neuroendocrine tumors (NF-PanNETs). It aims to identify how alterations in genes like ATRX and DAXX can predict the behavior of these tumors, particularly their potential to metastasize. By analyzing preoperative specimens, the study seeks to improve prognostic stratification, helping doctors make better treatment decisions for patients. The approach includes evaluating genomic alterations and their correlation with clinical outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-functional pancreatic neuroendocrine tumors who are undergoing evaluation for treatment.
Not a fit: Patients with functional pancreatic neuroendocrine tumors or those who are not diagnosed with pancreatic neuroendocrine tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate prognostic tools for patients with NF-PanNETs, enabling personalized treatment strategies.
How similar studies have performed: Previous research has shown promising results with similar biomarker approaches in other tumor types, indicating potential for success in this area as well.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Singhi, Aatur Dilip — University of Pittsburgh at Pittsburgh
- Study coordinator: Singhi, Aatur Dilip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.