Understanding Biliary Conditions
Pathophysiology of Biliary Disease
This research aims to better understand a liver condition called Primary Sclerosing Cholangitis (PSC) to find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11116979 on NIH RePORTER |
What this research studies
Primary Sclerosing Cholangitis (PSC) is a serious liver condition that affects many Americans and currently has no approved treatments. Our team is working to uncover why PSC develops, focusing on how liver cells respond to injury. We've found that some liver cells stop growing and become senescent, while others keep multiplying, and these different responses are linked to changes in their genetic programming. By studying these differences, we hope to identify new targets for medicines that could help patients with PSC.
Who could benefit from this research
Good fit: Patients living with Primary Sclerosing Cholangitis (PSC) are the primary focus of this foundational research.
Not a fit: Patients without Primary Sclerosing Cholangitis would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of the first effective treatments for Primary Sclerosing Cholangitis, improving the lives of many patients.
How similar studies have performed: Our team has previously reported on stress-induced cell changes in PSC, and preliminary data supports the current approach, building on existing knowledge.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Larusso, Nicholas F. — Mayo Clinic Rochester
- Study coordinator: Larusso, Nicholas F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.