Understanding Bacterial Gene Networks Across Different Species
Cross-species Analysis of Bacterial Gene Networks
This project looks at how different types of bacteria organize their genes to better understand antibiotic resistance and how they interact within the human body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11124632 on NIH RePORTER |
What this research studies
We are exploring the fundamental ways bacteria manage their internal systems, especially how they respond to stress like antibiotics and interact with each other in the human microbiome. By comparing the genetic networks of important gut bacteria like E. coli, Enterobacter cloacae, and Klebsiella pneumoniae, we hope to find common patterns. This work uses advanced CRISPR-based tools to study gene functions and regulation on a large scale. Our goal is to uncover basic mechanisms that help bacteria survive and adapt, which could lead to new ways to fight infections.
Who could benefit from this research
Good fit: This is a basic science project conducted in a laboratory setting and does not involve direct patient participation.
Not a fit: Patients will not receive immediate direct benefit from participating in this foundational laboratory research.
Why it matters
Potential benefit: If successful, this foundational work could reveal new weak points in bacterial systems, leading to better strategies for developing new antibiotics or combating antibiotic resistance.
How similar studies have performed: While the study of gene networks and CRISPR tools are established, systematically comparing these networks across multiple bacterial species in this manner is a relatively novel approach.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Peters, Jason M. — University of Wisconsin-Madison
- Study coordinator: Peters, Jason M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.