Understanding B cells and type 1 diabetes risk
Role of Ptpn2 in B cells during development of autoimmunity
This project explores how specific immune cells, called B cells, might contribute to developing type 1 diabetes, particularly in individuals with a family history.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11087690 on NIH RePORTER |
What this research studies
This research builds on earlier findings about a gene called PTPN2, which is linked to type 1 diabetes risk. We know that in healthy people, certain B cells that react to insulin are kept in check. However, in some family members of people with type 1 diabetes, and in those who are pre-diabetic, these B cells become active. This project uses special mouse models to understand how removing the Ptpn2 gene from B cells affects their behavior and the development of diabetes. By studying these changes, we hope to learn more about how type 1 diabetes starts.
Who could benefit from this research
Good fit: While this specific project uses animal models, future research stemming from these findings may seek individuals with a family history of type 1 diabetes or those in early stages of the disease.
Not a fit: Patients not at risk for type 1 diabetes or those with established, long-standing disease may not directly benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could help us understand the early stages of type 1 diabetes, potentially leading to new ways to predict or prevent the condition.
How similar studies have performed: Previous work has identified the PTPN2 gene as a risk factor for type 1 diabetes, and initial findings in mouse models have shown changes in B cell behavior when Ptpn2 is absent.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Smith, Mia — University of Colorado Denver
- Study coordinator: Smith, Mia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.