Understanding B cell changes that lead to lymphoma growth
Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis
This project explores why B-cell lymphoma sometimes returns after treatment, focusing on special B cells that might help tumors grow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11129828 on NIH RePORTER |
What this research studies
Many patients with B-cell lymphoma experience their cancer returning, even after receiving effective treatments. Researchers believe that certain rare B cells, which act like 'stem cells,' might be responsible for the cancer coming back. This project uses advanced single-cell technologies to look closely at these unique B cells and understand how specific genetic changes in lymphoma might make them more likely to cause tumors. The team hopes to uncover the molecular reasons why these cells contribute to lymphoma's ability to regrow and resist therapies.
Who could benefit from this research
Good fit: This foundational research is for patients with B-cell lymphoma, especially those who have experienced their cancer returning.
Not a fit: Patients whose lymphoma has not returned or who have other types of cancer may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent B-cell lymphoma from returning and improve treatment options for patients.
How similar studies have performed: While the idea of stem-like cells in lymphoma has been debated, this project uses novel approaches to provide strong evidence for their existence and role.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Apostolou, Effie — Weill Medical Coll of Cornell Univ
- Study coordinator: Apostolou, Effie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.