Understanding Autoimmunity in Type 1 Diabetes
Multiple Autoantigens, Multiple Epitopes of Type 1 Diabetes
This work aims to find new ways to detect early signs of type 1 diabetes in people, especially children, to help prevent the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11046536 on NIH RePORTER |
What this research studies
Our team is working to find new markers in the blood that show when the body's immune system mistakenly attacks its own cells, which is the start of type 1 diabetes. We are improving a special test that can find many of these markers at once, making it more accurate than older methods. We also want to understand how these markers change over time and how they relate to immune cells that cause damage. By doing this, we hope to better predict who will develop type 1 diabetes and how it progresses.
Who could benefit from this research
Good fit: This research is particularly relevant for individuals, especially children aged 0-11 years, who are at risk for type 1 diabetes or are in the earliest stages of the condition.
Not a fit: Patients who already have established type 1 diabetes and are not in the early stages of autoimmunity may not directly benefit from this specific research on early detection and prevention.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection and new strategies to prevent or slow the progression of type 1 diabetes.
How similar studies have performed: Previous work has successfully developed a sensitive assay for detecting autoantibodies, and recent findings have strengthened the understanding of immune cell responses in type 1 diabetes.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Michels, Aaron W — University of Colorado Denver
- Study coordinator: Michels, Aaron W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.