Understanding Autism Risk Factors in Early Development
Functional analysis of histone modifier Autism Spectrum Disorders risk genes in vertebrate development
This research explores how certain genetic changes linked to autism might affect brain development and behavior.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11139574 on NIH RePORTER |
What this research studies
We know that autism involves challenges with social interaction, communication, and behavior, and it might be connected to how brain cells develop early on. This project looks at specific genes, called histone modifiers, that are known to be linked to autism. By studying these genes in zebrafish, which share many similarities with humans, we hope to learn how changes in these genes lead to differences in brain cell types and behaviors. Our goal is to uncover the basic mechanisms of how these genetic changes contribute to autism.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients but aims to benefit individuals with Autistic Disorder by uncovering underlying biological mechanisms.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not receive benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of the genetic and developmental causes of autism, potentially leading to new ways to help individuals with the condition in the future.
How similar studies have performed: The link between chromatin regulators and autism has been previously discovered, suggesting a promising area for further investigation into specific genes.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Tornini, Valerie Angela — University of California Los Angeles
- Study coordinator: Tornini, Valerie Angela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.