Understanding Atypical Alzheimer's Disease with Brain Scans
Molecular and structural imaging in atypical Alzheimer's disease: a longitudinal study
This research helps us learn more about different forms of Alzheimer's disease by looking at brain changes over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11076291 on NIH RePORTER |
What this research studies
Alzheimer's disease can show up in different ways, not always starting with memory loss. This project looks at these less common forms, like those affecting language or vision, to understand why they are so varied. We use advanced brain scans, including PET and fMRI, to see how different brain changes, like protein buildup and iron levels, are connected to these unique symptoms. We also analyze genetic factors to understand their role in the disease's progression. By doing this, we hope to uncover the biological reasons behind the differences in how Alzheimer's disease affects people.
Who could benefit from this research
Good fit: Patients with atypical forms of Alzheimer's disease, such as those experiencing language difficulties (logopenic aphasia) or visual-spatial problems (posterior cortical atrophy), would be ideal candidates.
Not a fit: Patients without a diagnosis of Alzheimer's disease or related cognitive impairments would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this could lead to better ways to diagnose and treat the less common forms of Alzheimer's disease.
How similar studies have performed: The project builds upon a successful first cycle of research that identified heterogeneity in tau and amyloid deposition, indicating prior success with this research direction.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Whitwell, Jennifer Louise — Mayo Clinic Rochester
- Study coordinator: Whitwell, Jennifer Louise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.