Understanding Arginine Methylation's Role in Cells
A Functional Analysis of Arginine Methylation
This project aims to understand how a common cell process called arginine methylation works and its importance in the body, especially concerning DNA damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11132836 on NIH RePORTER |
What this research studies
Our cells use a process called arginine methylation to modify proteins, which helps them communicate and function properly. This project explores how these modifications happen and what specific proteins are involved in reading these signals. We are particularly interested in how these signals might affect how our bodies respond to DNA damage. By understanding these basic cellular mechanisms, we hope to uncover new ways to address health issues related to cell function and repair.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies building on this work may seek individuals with conditions related to DNA damage or cellular signaling.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of cell communication and DNA repair, potentially opening doors for new treatments for conditions involving DNA injury.
How similar studies have performed: While the general concept of protein modification is well-established, identifying specific "readers" of methylarginine marks and their roles in DNA damage response is a novel area of exploration.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Bedford, Mark T. — University of Tx Md Anderson Can Ctr
- Study coordinator: Bedford, Mark T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.