Understanding ApoE's Role in Alzheimer's Disease
ApoE isoform-specific structure: Insights on biology and pathobiology
This project aims to discover how different forms of a protein called ApoE affect the brain and contribute to Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11105820 on NIH RePORTER |
What this research studies
We know that different versions of the ApoE protein can greatly change a person's risk for Alzheimer's disease, with one form increasing risk and another offering protection. However, we don't fully understand the exact differences in how these ApoE forms are shaped, especially when they are naturally found in the body or interact with other molecules linked to Alzheimer's. This project uses advanced imaging techniques, like single-molecule fluorescence and cryo-electron microscopy, to get a clearer picture of these protein structures. By seeing these tiny differences, we hope to uncover why some ApoE forms are harmful and others are protective.
Who could benefit from this research
Good fit: Patients with Alzheimer's disease or those at high risk due to their ApoE genetic profile might eventually benefit from the insights gained from this basic science.
Not a fit: Patients whose condition is not related to ApoE or Alzheimer's disease would not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could reveal the fundamental reasons why certain ApoE forms increase Alzheimer's risk, potentially leading to new ways to prevent or treat the disease.
How similar studies have performed: While previous structural models of ApoE exist, this project uses innovative techniques to examine the protein in more natural and complete forms, addressing current limitations.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Soranno, Andrea — Mayo Clinic Jacksonville
- Study coordinator: Soranno, Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.