Understanding Aortic Weakness and Disease
ELUCIDATING MECHANISMS OF THORACIC AORTOPATHY VIA COMPUTATIONAL MODELING
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11136386
This project aims to better understand why the main artery in the chest, called the aorta, can weaken and lead to serious conditions like aneurysms and dissections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11136386 on ClinicalTrials.gov |
What this research studies
We want to uncover the detailed reasons behind thoracic aortopathy, which includes conditions like aortic aneurysm and dissection. Our approach involves using advanced computer models to explore how genetic factors, changes in cell signals, and the role of immune cells called macrophages contribute to this disease. We also look at how high blood pressure makes the aorta more vulnerable. The goal is to identify specific biological processes that could be targeted to preserve protective factors and prevent pathological ones, moving beyond current treatments.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals with or at risk for thoracic aortopathy, including those with genetic predispositions like Marfan syndrome, and those with high blood pressure.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to protect the aorta and prevent life-threatening complications like rupture, moving beyond current surgical and blood pressure management.
How similar studies have performed: While surgical and blood pressure management have improved, a deeper understanding of the underlying biological mechanisms of aortopathy remains an area with significant unmet needs, making this approach novel in its specific focus on computational modeling of cellular and genetic mechanisms.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUMPHREY, JAY D. — YALE UNIVERSITY
- Study coordinator: HUMPHREY, JAY D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aortic Diseases