Understanding Antibody Protection from Brucella Infection
Antibody Mediated Immunity Against Brucella
This project explores how our body's protective antibodies fight off Brucella infection and how the bacteria sometimes get around these defenses, hoping to create better vaccines.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11144554 on NIH RePORTER |
What this research studies
Brucellosis is a serious infection that can last a lifetime, and currently, there isn't a vaccine available for people. This project aims to uncover how the antibodies our bodies make after vaccination help protect us from Brucella bacteria by changing how our cells work. We also want to understand the clever ways Brucella manages to escape these protective antibodies. By learning more about these processes, we hope to develop new and more effective vaccines to prevent this challenging infection.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit anyone at risk of or suffering from brucellosis in the future.
Not a fit: Patients currently suffering from brucellosis will not directly benefit from this early-stage research, as it focuses on vaccine development rather than immediate treatment.
Why it matters
Potential benefit: If successful, this research could lead to the development of new, highly effective vaccines to prevent human brucellosis.
How similar studies have performed: This research builds upon initial findings that vaccine-elicited antibodies offer some protection and explores novel mechanisms of both protection and immune evasion.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Ateya Abushahba, Mostafa F — University of Missouri-Columbia
- Study coordinator: Ateya Abushahba, Mostafa F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.