Understanding and trusting AI in clinical settings

XAI-TRUST: Explainable AI Techniques to Rigorously Understand, Scrutinize, and Trust Clinical AI

NIH-funded research University of Washington · NIH-11063288

This study is working on making AI tools easier to understand for doctors and researchers, so they can see how things like chest X-ray images influence the AI's predictions, helping everyone trust and use these technologies safely in healthcare.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Washington NIH-funded
Lab location1 site (Seattle, United States)
Project IDNIH-11063288 on NIH RePORTER

What this research studies

This research focuses on developing explainable AI (XAI) techniques to help biomedical researchers and healthcare providers better interpret complex machine learning models used in clinical applications. By analyzing input features, such as chest X-ray images, the project aims to identify which aspects of these images contribute to AI-generated predictions, enhancing transparency and trust in AI systems. The methodology involves addressing current limitations of XAI, such as the complexity of understanding feature attributions and improving the interpretability of AI models. This work is crucial for ensuring that AI tools can be effectively and safely integrated into clinical practice.

Who could benefit from this research

Good fit: Ideal candidates for this research include patients undergoing chest imaging procedures, particularly those whose diagnoses may be influenced by AI interpretations.

Not a fit: Patients who do not require chest imaging or whose conditions are not assessed using AI tools may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more reliable and interpretable AI tools in healthcare, improving diagnostic accuracy and patient outcomes.

How similar studies have performed: Other research has shown promise in using explainable AI techniques in clinical settings, indicating that this approach has potential for success.

Where this research is happening

Seattle, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.