Understanding and treating Wilms tumors linked to CTR9 mutations
Official title: Mechanism and treatment of Wilms Tumors caused by CTR9 mutations
Funded at University of Wisconsin-Madison · NIH-11014715 · Data updated 2026-11-12
This study is looking at specific genetic changes in children with Wilms tumors to see how they influence the cancer's growth, with the goal of finding better treatments for kids who are facing this illness.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $218,089 |
| NIH project number | 1R21CA295443-01 |
| Project ID | NIH-11014715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have been diagnosed with Wilms tumors, particularly those with identified CTR9 mutations.
✕Less likely to help
Patients with Wilms tumors not associated with CTR9 mutations may not benefit from this specific research.
What this research studies
This research investigates the genetic mutations associated with Wilms tumors, a common pediatric cancer of the urinary tract. It focuses on CTR9 mutations, which have been linked to the disease, and aims to understand how these mutations affect cancer progression. By modeling these mutations in cell lines and studying their effects on gene expression, the research seeks to develop improved treatment strategies for affected children. The findings could lead to better therapeutic options for patients who experience relapses or have aggressive forms of the disease.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Wilms tumors, potentially reducing relapse rates and improving survival outcomes for children.
How similar studies have gone: Previous research has shown promise in understanding genetic mutations in cancers, suggesting that this approach could yield valuable insights and advancements in treatment.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Xu, Wei — University of Wisconsin-Madison
- Study coordinator: Xu, Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.